The American Airlines flight is scheduled to depart on Thursday, September 5, the day before the season opener against the Green Bay Packers on Sept. 6.
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The return flight is set for Sept. 7.
It is the first time the airline is offering nonstop service from PHL to South America.
As of right now, flight numbers AA215 and AA62 are the only scheduled nonstop flights to and from PHL and GRU ahead of the game.
To buy tickets, visit the American Airlines website or mobile app.